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1.
Ion homeostasis in diabetic kidney disease.
Hu, H, Liang, W, Ding, G
Trends in endocrinology and metabolism: TEM. 2024;(2):142-150
Abstract
The complications of type 2 diabetes are a major global public health problem with high incidence and mortality, affecting almost all individuals with diabetes worldwide. Diabetic kidney disease (DKD) is one such primary complication and has become a leading cause of end-stage renal disease in patients with diabetes. Progression from diabetes to DKD is a complex process typically involving multiple mechanisms. Recent remarkable clinical benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in diabetes and DKD highlight the critical impact of renal ion homeostasis on disease progression. This review comprehensively examines the impact of ion homeostasis on the transition from diabetes to DKD, outlining possible therapeutic interventions and addressing the ongoing challenges in this rapidly developing field.
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2.
Interplay of lipid metabolism and inflammation in podocyte injury.
Luo, Z, Chen, Z, Hu, J, Ding, G
Metabolism: clinical and experimental. 2024;:155718
Abstract
Podocytes are critical for maintaining permselectivity of the glomerular filtration barrier, and podocyte injury is a major cause of proteinuria in various primary and secondary glomerulopathies. Lipid dysmetabolism and inflammatory activation are the distinctive hallmarks of podocyte injury. Lipid accumulation and lipotoxicity trigger cytoskeletal rearrangement, insulin resistance, mitochondrial oxidative stress, and inflammation. Subsequently, inflammation promotes the progression of glomerulosclerosis and renal fibrosis via multiple pathways. These data suggest that lipid dysmetabolism positively or negatively regulates inflammation during podocyte injury. In this review, we summarize recent advances in the understanding of lipid metabolism and inflammation, and highlight the potential association between lipid metabolism and podocyte inflammation.
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3.
Fast proton transport enables the magnetic relaxation response of graphene quantum dots for monitoring the oxidative environment in vivo.
Li, Y, Wang, H, Ye, C, Wang, X, He, P, Yang, S, Dong, H, Ding, G
Nanoscale. 2024;(5):2382-2390
Abstract
A magnetic relaxation switch (MRS) that targets small molecules such as H2O2 is difficult to realize because of the small size of the targets, which cannot gather enough MRS probes to form aggregates and generate a difference in magnetic relaxation times. Therefore, the development of small molecule-targeted MRS is strongly dependent on changes in the interfacial structure of the probe, which modulates the proton transport behavior near the probe. Herein, functionalized graphene quantum dots (GQDs) consisting of GQDs with disulfide bonds, polyethylene glycol (PEG), and paramagnetic Gd3+ were used as the MRS probe to sense H2O2. The structure of GQDs changed after reacting with H2O2. The PEG assembled a tube for transmitting changes in GQDs via proton transport and thus enabled the magnetic relaxation response of the probe towards H2O2. Pentaethylene glycol was experimentally and theoretically proven to have the strongest ability to transport protons. Such a probe can be applied in the differentiation of healthy and senescent cells/tissues using in vitro fluorescent imaging and in vivo magnetic resonance imaging. This work provides a reliable solution for building a proton transport route, which not only enables the response of the MRS probe towards the targets but also demonstrates the design of carbon nanostructures with proton transport behaviors.
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4.
Research Progress of Maternal Metabolism on Cardiac Development and Function in Offspring.
Ren, Z, Luo, S, Cui, J, Tang, Y, Huang, H, Ding, G
Nutrients. 2023;(15)
Abstract
The developmental origin of health and disease (DOHaD) hypothesis refers to the adverse effects of suboptimal developmental environments during embryonic and early fetal stages on the long-term health of offspring. Intrauterine metabolic perturbations can profoundly impact organogenesis in offspring, particularly affecting cardiac development and giving rise to potential structural and functional abnormalities. In this discussion, we contemplate the existing understanding regarding the impact of maternal metabolic disorders, such as obesity, diabetes, or undernutrition, on the developmental and functional aspects of the offspring's heart. This influence has the potential to contribute to the susceptibility of offspring to cardiovascular health issues. Alteration in the nutritional milieu can influence mitochondrial function in the developing hearts of offspring, while also serving as signaling molecules that directly modulate gene expression. Moreover, metabolic disorders can exert influence on cardiac development-related genes epigenetically through DNA methylation, levels of histone modifications, microRNA expression, and other factors. However, the comprehensive understanding of the mechanistic underpinnings of these phenomena remains incomplete. Further investigations in this domain hold profound clinical significance, as they can contribute to the enhancement of public health and the prevention of cardiovascular diseases.
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5.
Association Between Handgrip Strength and Type 2 Diabetes: A Prospective Cohort Study and Systematic Review With Meta-analysis.
Wu, H, Gu, Y, Wang, X, Meng, G, Rayamajhi, S, Thapa, A, Zhang, Q, Liu, L, Zhang, S, Zhang, T, et al
The journals of gerontology. Series A, Biological sciences and medical sciences. 2023;(8):1383-1391
Abstract
BACKGROUND Both absolute (kg) and relative (kg per kg of body weight) handgrip strength (HGS) have been used as indicators of HGS. Multiple studies have explored HGS associations with type 2 diabetes (T2DM); however, prognostic values were inconsistent. We aimed to examine the associations between both absolute and relative HGS and incident T2DM. METHODS A total of 12,957 participants aged 40 years and older (mean age 51.0 years, 58.4% men) were followed and enrolled in the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study. Cox proportional hazards regression models were used to examine the association of HGS with incident T2DM. Other prospective studies on HGS and risk of T2DM were identified by searching several electronic databases up to November 31, 2021. Meta-analysis was performed by combining the results from the TCLSIH study and previous prospective cohort studies. RESULTS From the TCLSIH Cohort study, after adjustment, relative HGS was inversely associated with T2DM (hazard ratio per 0.1 higher relative HGS 0.667, 95% confidence interval [CI] 0.616, 0.722). However, no significant association between absolute HGS and incident T2DM was found. The meta-analyses showed that per 5 kg higher HGS was associated with a 5% (95% CI 2%, 8%) lower risk of T2DM and each 0.1 higher relative HGS was associated with a 22% (95% CI 14%, 29%) lower risk of T2DM. CONCLUSION The results from our cohort study and meta-analysis suggest that relative HGS was better than absolute HGS in predicting incident T2DM. Adiposity was an important factor that mediates the association between HGS and T2DM.
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6.
National Initiatives on Salt Substitutes: Scoping Review.
Kong, B, Yang, S, Long, J, Tang, Y, Liu, Y, Ge, Z, Rong, S, Wu, Y, Ding, G, Yang, Y, et al
JMIR public health and surveillance. 2023;:e45266
Abstract
BACKGROUND Salt substitutes are edible salts that contain less sodium chloride owing to its partial substitution with other minerals, which serve as an important and effective intervention and public health strategy targeting hypertension and its secondary diseases, despite a small degree of controversy. OBJECTIVE This study aimed to identify the current salt substitute initiatives in various nations and intergovernmental organizations (IGOs) worldwide and summarize their types and characteristics. METHODS A scoping review was performed based on Arksey and O'Malley's framework and the latest guidance from the Joanna Briggs Institute. Searches were conducted on Google; government websites on food, health, and other related topics; PubMed; Web of Science; and Google Scholar from January 2022 to May 2022. Initiatives related to salt substitutes that were included in the study focused on the involvement of governments or IGOs through the publication of standards, actions, collaborations, funding, and so on. Data were extracted into Microsoft Excel (version 2019; Microsoft Corp) based on predefined items and analyzed using narrative synthesis and frequency count methods. RESULTS A total of 35 initiatives from 11 countries (of which 9 are high-income countries) and 3 IGOs were identified. We classified all salt substitute initiatives into 5 types, namely benefit-risk assessments and cautions; plans and actions; regulations and standards; labels; and food reformulation, cooperation with the food industry, and media. More than half (18/35, 51%) of the salt substitute initiatives were launched within the past 5 years. Except for regulations and standards, salt substitute initiatives are, in general, part of the salt reduction framework. No nation or IGO has yet reported on the monitoring and implications of the use of salt substitutes. CONCLUSIONS Despite the limited number of salt substitute initiatives worldwide at present, a review on the different types and characteristics of such initiatives could be helpful in providing a reference for policy makers and stakeholders. Given the great potential of salt substitutes in improving hypertension and stroke, we call on more nations to pay attention to these substitutes and propose salt substitute initiatives in line with their national conditions.
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7.
A critical review of plant adaptation to environmental boron stress: Uptake, utilization, and interplay with other abiotic and biotic factors.
Li, S, Yan, L, Venuste, M, Xu, F, Shi, L, White, PJ, Wang, X, Ding, G
Chemosphere. 2023;:139474
Abstract
Boron (B) is an indispensable mineral nutrient for plants and is primarily taken up by roots mainly in the form of boric acid (H3BO3). Recently, research shows that B has a significant impact on plant growth and productivity due to its narrow range between deficiency and toxicity. Fertilization and other procedures to address B stress (deficiency and toxicity) in soils are generally expensive and time-consuming. Over the past 20 years, substantial studies have been conducted to investigate the mechanisms underlying B acquisition and the molecular regulation of B stress in plants. In this review, we discuss the effects of B stress on plant growth, physiology, and biochemistry, and finding on enhancing plant tolerance from the perspective of plant B uptake, transport, and utilization. We also refer to recent results demonstrating the interactions among B and other biological and abiotic factors, including nitrogen, phosphorus, aluminum, and microorganisms. Finally, emerging trends in this field are discussed.
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8.
Role of cuproptosis in understanding diseases.
Cao, S, Wang, Q, Sun, Z, Zhang, Y, Liu, Q, Huang, Q, Ding, G, Jia, Z
Human cell. 2023;(4):1244-1252
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Abstract
Cell death is involved in a wide range of physiological and pathological processes. Recently, the term "cuproptosis" was coined to describe a novel type of cell death. This type of cell death, characterized by copper accumulation and proteotoxic stress, is a copper-dependent manner of death. Despite the progress achieved toward a better understanding of cuproptosis, mechanisms and related signaling pathways in physiology and pathology across various diseases remain to be proved. This mini review summarizes current research on cuproptosis and diseases, providing insights into prospective clinical therapies via targeting cuproptosis.
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9.
[Epidemiological research progress on the relationship between children's dietary patterns and health].
Chen, MX, Xiong, JY, Zhao, L, Cheng, G, Zhang, GG, Ding, G
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2022;(2):139-145
Abstract
As food preferences and eating habits form early in life, the development of healthy eating habits in early childhood is a way to prevent diet-related diseases. The dietary pattern approach examines the effect of an overall diet on health outcomes, instead of individual foods or nutrients, thereby presenting a comprehensive evaluation of children's dietary intake. This article reviews the current literature to summarize the main methods for assessing dietary patterns and explore relationships between children's dietary patterns and obesity, puberty onset, cardiovascular diseases, and neurodevelopment. The purpose of this review is to provide evidence-based support for reducing the risk of diet-related diseases in children and recommendations for future research directions.
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Genetic Control of Seed Phytate Accumulation and the Development of Low-Phytate Crops: A Review and Perspective.
Wang, W, Xie, Y, Liu, L, King, GJ, White, P, Ding, G, Wang, S, Cai, H, Wang, C, Xu, F, et al
Journal of agricultural and food chemistry. 2022;(11):3375-3390
Abstract
Breeding low phytic acid (lpa) crops is a strategy that has potential to both improve the nutritional quality of food and feed and contribute to the sustainability of agriculture. Here, we review the lipid-independent and -dependent pathways of phytate synthesis and their regulatory mechanisms in plants. We compare the genetic variation of the phytate concentration and distribution in seeds between dicot and monocot species as well as the associated temporal and spatial expression patterns of the genes involved in phytate synthesis and transport. Quantitative trait loci or significant single nucleotide polymorphisms for the seed phytate concentration have been identified in different plant species by linkage and association mapping, and some genes have been cloned from lpa mutants. We summarize the effects of various lpa mutations on important agronomic traits in crop plants and propose SULTR3;3 and SULTR3;4 as optimal target genes for lpa crop breeding.